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AbstractCells can sense and interpret mechanical stimuli from their environment, but the ability to engineer customized mechanosensing capabilities has remained a synthetic biology challenge. Here, we introduce a set of synthetic Notch (SynNotch)-derived proteins that can be used to convert extracellular tensile forces into specifiable gene expression changes. By elevating the tension levels needed to induce SynNotch activation, in combination with structure-guided mutagenesis, we designeddoi:10.1101/2022.05.01.490205 fatcat:cwnoo2eecvganmkmcusizvb6pa