Lansoprazole a proton pump inhibitor used in the treatment of gastric and duodenal ulcer, reflux esophagitis. In the present investigation enhance the solubility and dissolution profile of lansoprazole by using solid dispersion technique. Effervescent method can be used as alternative to develop dosage form which can accelerate drug disintegrating and dissolution, is usually applied in quick release preparation. Lansoprazole is insoluble in water, improved the solubility by using the solid

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... rsion technique. Solid dispersion prepared by the solvent evaporation method was further used in formulation as active API. Then Effervescent tablet was prepared by using Direct Compression method. Design using the excipient such as alkalizing agent sodium bicarbonate and acidifying agenttartaric acid. Drug-excipient compatibility checked by FTIR method also micromeritics properties were performed such as Bulk density, Tapped density, Hausner's ratio, Carr's index, Angle of repose. Among 7 batches F4 batch was optimized batch with drug release, Hardness, Friability, Weight variation, Drug content uniformity, Disintegration time and pH of solution, Dissolution study were evaluated. The dissolution data subjected to drug release kinetic fit in Higuchi model of regression coefficient of correlation R 2 =0.809.