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Multiple polarity kinases inhibit phase separation of F-BAR protein Cdc15 and antagonize cytokinetic ring assembly in fission yeast
[article]
2022
bioRxiv
pre-print
AbstractThe F-BAR protein Cdc15 is essential for cytokinesis in Schizosaccharomyces pombe and it plays a key role in attaching the cytokinetic ring (CR) to the plasma membrane. Cdc15's abilities to bind to the membrane and oligomerize via its F-BAR domain are inhibited by phosphorylation of its intrinsically disordered region (IDR). Multiple cell polarity kinases regulate Cdc15 IDR phosphostate, and of these the DYRK kinase Pom1 phosphorylation sites on Cdc15 have been shown in vivo to prevent
doi:10.1101/2022.08.26.505417
fatcat:lwvofugekvgkzkysfn5sffyvlq