Relationship between hydrogen sulfide and inflammation in patients with acute promyelocytic leukemia complicated with infection

Ling Fan, Li-Feng Chen, Jing Fan, Ling Zhang, Li-Rong Guo
2017 Journal of Hainan Medical University  
Objective: To investigate the clinical effect of hydrogen sulfide on acute promyelocytic leukemia (acute promyelocytic leukemia APL) complicated with infection. Methods: A total of 30 cases patients of APL complicated with infection were selected as experimental group, 26 cases patients with only APL as control group. Detect the H2S, C-reactive protein (CRP), tumor necrosis factor alpha (TNF-α), interleukin-1 beta (IL-1β) and interleukin-10 (IL-10) level in the blood of the experimental group
more » ... xperimental group and control group, comparing the above indicators have no significant difference between the two groups. Results: Experimental group of blood H2S, CRP, TNF-α and IL-1β levels were significantly increased, IL-10 decreased, which was statistically significant compared with the control group; the H2S, CRP, TNF-αand IL- 1βlevels of the experimental group after the treatment were significantly decreased, IL-10 level increased, There was statistical significance compared with the experimental group before the treatment; compared with the control group, the difference was not statistically significant. The experimental group H2S was positively correlated with CRP, TNF-α and IL-1β, H2S was negatively correlated with IL-10. Conclusions: Endogenous H2S is involved in the pathophysiological process of inflammation in APL with infection, and its role may be similar to that of CRP, TNF-α and IL-1β, which is contrary to the effect of IL-10.
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