Discovery of protein-protein interactions using a combination of linguistic, statistical and graphical information

James W Cooper, Aaron Kershenbaum
2005 BMC Bioinformatics  
The rapid publication of important research in the biomedical literature makes it increasingly difficult for researchers to keep current with significant work in their area of interest. This paper reports a scalable method for the discovery of protein-protein interactions in Medline abstracts, using a combination of text analytics, statistical and graphical analysis, and a set of easily implemented rules. Applying these techniques to 12,300 abstracts, a precision of 0.61 and a recall of 0.97
more » ... e obtained, (f = 0.74) and when allowing for two-hop and three-hop relations discovered by graphical analysis, the precision was 0.74 (f = 0.83). This combination of linguistic and statistical approaches appears to provide the highest precision and recall thus far reported in detecting protein-protein relations using text analytic approaches.
doi:10.1186/1471-2105-6-143 pmid:15941473 pmcid:PMC1164402 fatcat:v6rz6xmjxbecrbbx4ofgfen5dy