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The permeability barrier of nuclear pore complexes appears to operate via hydrophobic exclusion
2002
EMBO Journal
Nuclear pore complexes (NPCs) restrict the nucleo-cytoplasmic¯ux of most macromolecules, but permit facilitated passage of nuclear transport receptors and their cargo complexes. We found that a simple hydrophobic interaction column can mimic the selectivity of NPCs surprisingly well and that nuclear transport receptors appear to be the most hydrophobic soluble proteins. This suggests that surface hydrophobicity represents a major sorting criterion of NPCs. The rate of NPC passage of
doi:10.1093/emboj/21.11.2664
pmid:12032079
pmcid:PMC126029
fatcat:442666afqbawrb4iuj3eg66ldm