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The Uptake Mechanism of the Cell-Penetrating pVEC Peptide
2013
Journal of Chemistry
Peptide based drug design efforts have gained renewed interest with the discovery of cargo-carrying or cell-penetrating peptides. Understanding the translocation mechanism of these peptides and identifying the residues or elements that contribute to uptake can provide valuable clues toward the design of novel peptides. To this end, we have performed steered molecular dynamics (SMD) simulations on the pVEC peptide from murine vascular endothelial-cadherin protein and its two variants.
doi:10.1155/2013/851915
fatcat:dtvucppyx5evpk7sk35zgabate