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Functional analysis of the plasma membrane Alr1 and Alr2 proteins in Yeast Saccharomyces cerevisiae
Proteins Alr1 and Alr2 of Saccharomyces cerevisiae encode a very sophisticated system to take up magnesium, one of the most abundant cations, into the cell. In this thesis a series of biochemical and genetic analyses support the functional and structural homology of Alr1p and its close homolog protein Alr2 to the CorA-Mrs2-Alr1 family. Whereas Alr1p acts as the main Mg2+-transporter, Alr2p contributes poorly to Mg2+-uptake. Substitution of a single arginine with a glutamic acid residue in thedoi:10.25365/thesis.7644 fatcat:rygcq4ejebgmjpnuem4upmhibm