On the normal and decerebrated rabbits, antihistamics (i.e. aminoether, ethylendiamine, phenotliazine and monoamine), local anesthetics (i.e. cocaine and lalcohol), (i.e. adrenalin, pilocarpine, and atropine), and interneuronal blocking agent (i.e. meprobamate) are so introduced into the tympanic cavities, that the effect of the drugs upon their labyrinths could be studied clinically and electromyographycally. The obtained results were as follows: 1. Clinical findings: The spontaneous nystagmus

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... to the untreated ear side was observed when the aminoether, cocaine, adrenalin and alcohol were introduced. When pilocarpine and alcohol were introduced spontaneous nystagmus to the treated side was observed. But by the application of the other drugs the spontaneous nystagmus was not observed. The head-deviation as the effect of antihistamin drug of aminoether, cocaine, adrenalin, and alcohol in anesthetic period, is shown with the infused ear downwards, and as the effect of pilocarpine and alcohol in stimulating period with the non-infusedd ear downwards. 2. Electromyographical findings: By the effect of antihistamin drug of aminoether, cocaine, adrenalin, and alcohol' in anesthetic period, the spontaneous discharges in the deep nape muscles of the non-infused ear side are decreased, and on the contrary are increased by pilocarpin and alcohol in stimulating period. By the other drugs the spontaneous, discharges in the deep nape muscles of the both sides are not changed. 3. The effect of the antihistamin drug of aminoether and local anesthetics upon the labyrinthine muscle tonus is remarkable, but of sympathetic drugs, i.e. adrenalin and pilocarpine'is slight. (autoreferat)