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Bactericidal activity and synergy studies of proton pump inhibitors and antibiotics against Helicobacter pylori in vitro
1997
Journal of Antimicrobial Chemotherapy
Preserved Fulltext
The bactericidal activity of the proton pump inhibitors omeprazole and lansoprazole alone and in combination with a -lactam or macrolide antibiotic were investigated in vitro. Time-kill curves against Helicobacter pylori NCTC 11637 and a recent clinical isolate revealed significant concentration-dependent killing with all drugs other than amoxycillin. Combinations of proton pump inhibitor and erythromycin showed synergic activity. In contrast, proton pump inhibitor plus amoxycillin showed
doi:10.1093/jac/39.3.331
pmid:9096182
fatcat:vpnugk3g3vbsrc6e6sbjo5frhi