The minimum inhibitory concentrations (MICs) of enrofloxacin, ciprofloxacin, norfloxacin, gentamicin, spectinomycin, oxytetracycline, tylosin, florfenicol and tiamulin were determined against 24 Mycoplasma bovis isolates from cattle in Bosnia and Herzegovina using the microbroth dilution test. The lowest MIC values (≤0.03 μg/ml) were obtained for tiamulin, gentamicin and oxytetracycline. Spectinomycin and tylosin had the highest MIC values (≥128 μg/ml). Tiamulin had the lowest MIC 50 value

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... 3 μg/ml) and MIC 90 value (0.5 μg/ml). Among the fluoroquinolones, enrofloxacin had the lowest MIC 50 value (0.25 μg/ml) and MIC 90 value (1 μg/ml), followed by ciprofloxacin (MIC 50 of 0.5 μg/ml; MIC 90 of 2 μg/ ml). The highest MIC 50 value (4 μg/ml) was found for norfloxacin, oxytetracycline and tylosin, while spectinomycin and tylosin yielded the highest MIC 90 values (>128 μg/ml).