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Dr. Jekyl-Mr. Hyde Role of Sox Family–From Neurogenesis to Cancer: A Review
2018
Journal of Molecular Biomarkers & Diagnosis
After the historic discovery of IPSCs by Shinya Yamanaka, Sox2 became a highly important factor for its crucial role in reprogramming of somatic cells. The transcriptional control of various phases of nerve cell development, which include stem-cell maintenance, glial specification and lineage-specific terminal differentiation, are not well understood. This is where Sox proteins come into play. Recently, SOX2 expression has been corroborated in several tumor types including ovarian carcinoma,
doi:10.4172/2155-9929.1000393
fatcat:y4m5dsprdjdclo33ap7vjbhzpu