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Ileosigmoid knotting is a rare condition in which a compound volvulus causes acute intestinal obstruction. In this process, the terminal ileum wraps around the base of the mesosigmoid and sigmoid colon, forming a knot. This condition tends to rapidly progress to gangrene of both the ileum and sigmoid colon; hence, the mainstay of treatment is timely emergency surgery. In this report, we describe the case of a 20-year-old Ghanaian female patient and discuss the available surgical options regarding ileosigmoid knotting.doi:10.2147/ijgm.s279870 pmid:33269002 pmcid:PMC7701158 fatcat:mn4ie6w3lnezzikjmvcwb3gp5u