Antifungal Cyclic Peptides fromPsammosilene tunicoides

Junmian Tian, Yunheng Shen, Xianwen Yang, Shuang Liang, Lei Shan, Huiliang Li, Runhui Liu, Weidong Zhang
2010 Journal of natural products  
Three new cyclic peptides, tunicyclins B-D, and a known cyclic peptide, psammosilenin B, were isolated from the root of Psammosilene tunicoides. The structures of new cyclic peptides were elucidated by extensive NMR and MS analysis. Tunicyclin B contains an unusual R, -dehydrotryptophan (∆ Z -Trp) residue, previously reported from marine sponges and bacteria. Tunicyclin D showed a broad spectrum of antifungal activity against Candida albicans (SC5314), Candida albicans (Y0109), Candida
more » ... ), Candida tropicalis, Candida parapsilosis, and Cryptococcus neoformans (BLS108) with MIC 80 values of 4.0, 16.0, 0.25, 1.0, and 1.0 µg mL -1 , respectively.
doi:10.1021/np100363a pmid:21070025 fatcat:blxxpnpkcfevzhu5bmyza6ht4q