A Pathological Scoring System to Predict Renal Outcome in Diabetic Nephropathy

Junichi Hoshino, Koki Mise, Toshiharu Ueno, Aya Imafuku, Masahiro Kawada, Keiichi Sumida, Rikako Hiramatsu, Eiko Hasegawa, Masayuki Yamanouchi, Noriko Hayami, Tatsuya Suwabe, Naoki Sawa (+5 others)
2015 American Journal of Nephrology  
tubular atrophy classes 0, 1, 2, and 3 were 0, 7, 9, and 11, and those of interstitial inflammation classes 0, 1, and 2 were 0, 3, and 4, respectively. The D-score of hyalinosis class 2 was 3 and that of arteriosclerosis class 2 was 1. So, a patient's Dscore could be 0-25. HRs for ESRD in patients with D-score ≤ 14, 15-18, 19-21, and 22-25 were, respectively, 1.00 (reference) 16.21 (95% confidence interval (CI), 1.86-140.90), 19.78 (95% CI, 2.15-182.40), and 45.46 (95% CI, 4.63-446.68) after
more » ... usting for clinical factors. The c-statistics suggested a better predictive ability for a 10-year renal death with models that included the D-score. Conclusion: Prediction of DN patients' renal outcome was better with the D-score than without it. Patients with a D-score ≤ 14 had excellent renal prognosis.
doi:10.1159/000431333 pmid:26067713 fatcat:tmfjg7uitjcndecmq4lftfe2le