Long-Term Hearing Results and Otological Complications of Nasopharyngeal Carcinoma Patients: Comparison between Treatment with Conventional Two-Dimensional Radiotherapy and Intensity-Modulated Radiotherapy

Raymond K. Tsang, Dora L. Kwong, Ambrose C. Ho, Victor S. To, Wai-Kuen Ho, William I. Wei
2012 Journal for Oto-Rhino-Laryngology  
Objective: To assess the long-term audiological outcome and otological complications of nasopharyngeal carcinoma (NPC) patients who have received intensity-modulated radiotherapy (IMRT) versus conventional two-dimension radiotherapy (2DRT). Study Design: Prospective study on the audiological outcome and otological complications 5-9 years after radiotherapy. Methodology: Patients had pure tone audiogram before radiotherapy and 5 years after radiotherapy. Otological examination was performed 5 to
more » ... was performed 5 to 9 years after radiotherapy by otolaryngologist. Results: There is significant deterioration of hearing threshold 5 years after radiotherapy but there is no statistical significant difference in the deterioration of hearing between IMRT and 2DRT. 6 patients in the 2DRT group and 1 patient in IMRT group had osteoradionecrosis of the external auditory canal (p=0.042). Conclusion: There are fewer incidences of osteoradionecrosis of external auditory canal in patients treated with IMRT. There is no difference in bone conduction threshold in patients treated with IMRT or 2DRT.
doi:10.1159/000341096 pmid:22907195 fatcat:ois6ukav3nh3pkicdhzhnbqvoi