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Off-resonance saturation as an MRI method to quantify ferritin-bound iron in the post-mortem brain
Purpose To employ an Off-Resonance Saturation (ORS) method to measure the ferritin-bound iron pool, which is an endogenous contrast agent which can give information on cellular iron status. Methods An ORS acquisition protocol was implemented on a 7T preclinical scanner and the contrast maps were fitted to an established analytical model. The method was validated by correlation and Bland-Altman analysis on a ferritin-containing phantom. Ferritin-iron maps were obtained from post-mortem tissue ofdoi:10.1101/2021.03.22.436424 fatcat:ajgz7fzfqvavxobvkwhy4najwe