Study on Prevention of Colon Diseases by Functional Foods through Control of the Antioxidant Pathway

Yasuki Higashimura
2018 Nippon Eiyo Shokuryo Gakkaishi  
Accumulation of oxidative stress in the colonic mucosa is intrinsically associated with the onset of colorectal cancer and inflammatory bowel disease, suggesting that activation of the anti-oxidation system is important for prevention of these diseases. In the present study, we demonstrated that up-regulation of heme oxygenase-expression in macrophages located in the colonic lamina propria was an effective strategy for suppression of intestinal inflammation. We then investigated the therapeutic
more » ... effect of agaro-oligosaccharides AGO , which are products of agarose hydrolysis, using an experimental murine model of colitis. AGO administration was found to markedly attenuate intestinal inflammation in these mice through induction of heme oxygenaseexpression, and this was associated with significant suppression of neutrophil accumulation and TNF-α spexpression. Furthermore, heme oxygenase-induction in macrophages was able to drive a shift in phenotype to anti-inflammatory M macrophages. Taken together, the present results suggest that heme oxygenase-induction in macrophages located in the colonic lamina propria might be an additional strategy for prevention and treatment of intestinal inflammation.
doi:10.4327/jsnfs.71.237 fatcat:wt7j47lvnje7de4q6ne3hf2fhi