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Chromatin topology and the timing of enhancer function at the HoxD locus
Proceedings of the National Academy of Sciences of the United States of America
The HoxD gene cluster is critical for proper limb formation in tetrapods. In the emerging limb buds, different subgroups of Hoxd genes respond first to a proximal regulatory signal, then to a distal signal that organizes digits. These two regulations are exclusive from one another and emanate from two distinct topologically associating domains (TADs) flanking HoxD, both containing a range of appropriate enhancer sequences. The telomeric TAD (T-DOM) contains several enhancers active indoi:10.1073/pnas.2015083117 pmid:33229569 fatcat:nryil6rlqfbcdohhy7j4lyevvq