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B cell clonal expansion is correlated with antigen-specificity in young but not old mice
[article]
2021
biorxiv/medrxiv
pre-print
Aging of the humoral immune response has been shown to affect its critical role in defending the host from a variety of pathogens. Technical limitations have nevertheless made it challenging to investigate the relationship between genotype and phenotype of antibody repertoires in the context of aging. We therefore performed single-cell sequencing of over 95,000 B cells to simultaneously investigate B cell receptor (BCR) repertoires and gene expression profiles in the bone marrow and spleens of
doi:10.1101/2021.11.09.467876
fatcat:ajpjrryq7ffmph3ctzogelhyke