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Aberrant V(D)J cleavages in T cell receptor β enhancer- and p53-deficient lymphoma cells
2010
Oncology Reports
Previously, we generated thymic lymphoma cell lines from Eß R/R p53 -/-(EP) double mutant mice where the T cell receptor (TCR) ß enhancer (Eß) was deleted, and the p53 gene was inactivated. Here, we characterized the EP cell lines to study the roles of the Eß and p53 on TCRß rearrangements during lymphomagenesis. Recombination activation genes (RAGs) were expressed, while the TCRß chain was not expressed in the EP cell lines. Dß-Jß rearrangements were not detected at all, and Dß1 and Dß2
doi:10.3892/or_00000785
fatcat:kzlqkux57zevtfpkzkozd5gw6a