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Utility of network integrity methods in therapeutic target identification
2014
Frontiers in Genetics
Analysis of the biological gene networks involved in a disease may lead to the identification of therapeutic targets. Such analysis requires exploring network properties, in particular the importance of individual network nodes (i.e., genes). There are many measures that consider the importance of nodes in a network and some may shed light on the biological significance and potential optimality of a gene or set of genes as therapeutic targets. This has been shown to be the case in cancer
doi:10.3389/fgene.2014.00012
pmid:24550933
pmcid:PMC3909879
fatcat:beqwxgvddbcghkpkvpzhkofyaq