Vitamin D with asthma and COPD: not a false hope? A systematic review and meta-analysis

L.L. Zhang, J. Gong, C.T. Liu
2014 Genetics and Molecular Research  
Vitamin D deficiency and insufficiency are increasingly being recognized in the general population over the last few decades. However, a number of other disorders have now been linked to vitamin D deficiency and insufficiency, including asthma and COPD. The aim of this study was to evaluate the evidence on the effect of vitamin D on asthma and COPD. We searched electronic databases including SCI, EMBASE, Ovid, and PubMed. Reviewers working independently and in duplicate extracted study
more » ... cted study characteristics, quality, and the outcomes. The weighted mean differences across trials and random-effect meta-analysis were used to pool the relative risks (RR). This is the first meta-analysis about the risk of vitamin D deficiency for asthma and COPD. Ten studies were available for this meta-analysis and systematic review. The prevalence of vitamin D deficiency was significantly greater among cases than control subjects [RR = 1.59, 95%CI = 1.07-2.36, 488/812 (60%) vs 278/875 (32%)] for asthma. However, vitamin D insufficiency was not significantly associated with asthma [RR = 1.09, 95%CI = 0.91-1.30, 702/996 (70%) vs 665/1016 7608 L.L. Zhang et al. ©FUNPEC-RP Genetics and Molecular Research 13 (3): 7607-7616 (2014) (65%)] . Moreover, studies failed to demonstrate that COPD patients had an increased risk for vitamin D deficiency or insufficiency compared to controls (RR = 0.89, 95%CI = 0.63-1.25). Vitamin D deficiency was associated with a significant decrease in lung function in asthmatic children. Vitamin D deficiency was highly prevalent in asthma patients, and vitamin D status was associated with lung function. COPD cannot be considered as completely free of vitamin D deficiency.
doi:10.4238/2014.february.13.10 pmid:24615096 fatcat:7i4w7xqkxraoljisr42grwcbyy