Facile Uptake of Manganese(III) by Apo- Transferrin: Possible Origin of Manganism

Keita Abe, Yuji Chiba, Yuzo Nishida
2008 Zeitschrift für Naturforschung C - A Journal of Biosciences  
We have investigated the mechanism of manganese ion uptake by apo-transferrin using a capillary electrophoresis method, and obtained clear evidence that oxidation state +3 and the binuclear unit of a manganese chelate are essential factors for the facile uptake by apotransferrin, similar to that observed for Fe(III) chelates. These results may give valuable information to understand the pathogenesis of manganism and to develop new countermeasures for the neurotoxicity by manganese ions.
doi:10.1515/znc-2008-1-228 fatcat:ih2r6e4dxrfifoki4frookfqju