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Is the Fetal Origins Hypothesis of Diabetes Supported by Animal Research? A Systematic Review and Meta-Analysis of the Evidence
Journal of Diabetes & Metabolism
The fetal programming hypothesis states that fetal undernutrition during pregnancy results in permanent changes in the offspring's metabolism. A large number of animal studies have evaluated the effect of prenatal undernutrition on later glucose metabolism. Aim: We systematically reviewed the existing animal literature examining effects of prenatal undernutrition on glucose and insulin metabolism. Methods: An electronic search was performed in Medline and Embase to identify all articles thatdoi:10.4172/2155-6156.1000307 fatcat:mryueonpl5cevdzg3scgc2ojba