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An Improved Method For Real-Time Monitoring of Membrane Capacitance in Xenopus laevis Oocytes
2002
Biophysical Journal
Measurements of membrane capacitance (C m ) in Xenopus laevis oocytes offer unique experimental possibilities but are difficult to perform with current methods. To improve C m measurements in the two-electrode voltage clamp (TEVC) mode, we developed a paired-ramp protocol and tested its performance in a model circuit (with tunable C m , membrane resistance R m , and series resistance R s ) and in Xenopus oocytes. In the cell model and with R s ϭ 0 ⍀, inaccuracy of C m estimates was Ͻ1% under
doi:10.1016/s0006-3495(02)75490-8
pmid:11867451
pmcid:PMC1301937
fatcat:4bhpmcffmvgphmh577vfpi3wyi