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Comprehensive Proteomic Profiling Identifies Serum Proteomic Signatures for Detection of Hepatocellular Carcinoma and Its Subtypes
2003
Clinical Chemistry
Detection of hepatocellular carcinoma (HCC) in patients with chronic liver disease (CLD) is difficult. We investigated the use of comprehensive proteomic profiling of sera to differentiate HCC from CLD. Methods: Proteomes in sera from 20 CLD patients with ␣-fetoprotein (AFP) <500 g/L (control group) and 38 HCC patients (disease group) were profiled by anionexchange fractionation (first dimension), two types (IMAC3 copper and WCX2) of ProteinChip ® Arrays (second dimension), and time-of-flight
doi:10.1373/49.5.752
pmid:12709366
fatcat:r7fzuikbibh6xn6yi2mrxdx6qa