In this paper we present our work toward FPGA acceleration of phylogenetic reconstruction, a type of analysis that is commonly performed in the fields of systematic biology and comparative genomics. In our initial study, we have targeted a specific application that reconstructs maximum-parsimony (MP) phylogenies for gene-rearrangement data. Like other prevalent applications in computational biology, this application relies on a control-dependent, memoryintensive, and non-arithmetic

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... optimization algorithm. To achieve hardware acceleration, we developed an FPGA core design that implements the application's primary bottleneck computation. Because our core is lightweight, we are able to synthesize multiple cores on a single FPGA. By using several cores in parallel, we have achieved a 25X end-to-end application speedup using simulated input data. 2007 International Symposium on Field-Programmable Custom Computing Machines 0-7695-2940-2/07 $25.00