A simple, reproducible, physiologic technic is delineated for the production and study of thromboembolism. The method is based on the observation that the infusion of serum, in striking contrast to plasma, induces massive thrombosis in vascular segments containing stagnant blood far removed from the site of infusion. Data are presented on the nature of the thrombosis-inducing activity of canine and human serum, on the effect of serum infusions on recipient animals, and on the morphology of the

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... nduced thrombus. The adaptability of this method to the study of a variety of thromboembolic phenomena in man is described.