Mitochondrial Energetics and Therapeutics

Douglas C. Wallace, Weiwei Fan, Vincent Procaccio
2010 Annual Review of Pathology  
Mitochondrial dysfunction has been linked to a wide range of degenerative and metabolic diseases, cancer, and aging. All these clinical manifestations arise from the central role of bioenergetics in cell biology. Although genetic therapies are maturing as the rules of bioenergetic genetics are clarified, metabolic therapies have been ineffectual. This failure results from our limited appreciation of the role of bioenergetics as the interface between the environment and the cell. A systems
more » ... ch, which, ironically, was first successfully applied over 80 years ago with the introduction of the ketogenic diet, is required. Analysis of the many ways that a shift from carbohydrate glycolytic metabolism to fatty acid and ketone oxidative metabolism may modulate metabolism, signal transduction pathways, and the epigenome gives us an appreciation of the ketogenic diet and the potential for bioenergetic therapeutics. 297 Annu. Rev. Pathol. Mech. Dis. 2010.5:297-348. Downloaded from www.annualreviews.org by Florida State University on 07/18/11. For personal use only.
doi:10.1146/annurev.pathol.4.110807.092314 pmid:20078222 pmcid:PMC3245719 fatcat:g7ixcue4jjfa3gumdrthn7ssjy