Inhibitory effect of Rhus verniciflua Stokes extract in MCF-7 human breast cancer cells
참옻 추출물의 MCF-7 인체 유방암 세포에서 증식 억제효과

Min Sung Kim, Won Gun An, Jang Cheon Lee
2016 Herbal Formula Science  
Objectives : The purpose of this study was to investigate the anti-cancer effects of extract of Rhus verniciflua Stokes (RVS) in human breast cancer cell lines. Methods : In cultured human breast cancer MCF-7 cells, we investigated growth inhibitory effect of RVS. MCF-7 cells were cultured with various concentrations (0, 200, 300, and 400 ug/ml) of RVS at 37 o C for 24 h. We performed CCK-8 assay and flow cytometry for detection of Annexin V-PI staining. Results : As a result, RVS inhibits the
more » ... , RVS inhibits the cell growth and induction of apoptosis in dose dependent manner in MCF-7 breast cancer cells. Conclusion : RVS has anti-cancer activities and induced apoptosis in human breast cancer MCF-7 cells. Therefore we suggest that RVS can use as a novel class of anti-cancer drugs.
doi:10.14374/hfs.2016.24.4.283 fatcat:btym76o73zbaheijgsnycolana