Antibiotic is a type of antimicrobial drug used for treating and preventing any infection caused by pathogenic bacteria. The widely accepted use of antibiotics has saved millions of human lives all over the world; however, they highly influenced the human microbiome. Human microbiome performs an array of important functions that help us to survive and keep away dangerous disease. Mounting evidence shows that antibiotics alter the constituent of this microbiome and influence the function of the

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... mmune system, our ability to resist infection, and our capacity for processing food. Therefore, it is now more important than ever to revisit how we use antibiotics. This review focused on some collateral effects and problems associated with antibiotic use on human gut microbiome. Evidence of histological alternation of intestinal epithelia was considered.