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1997 IEEE International Conference on Systems, Man, and Cybernetics. Computational Cybernetics and Simulation
We performed computer simulations to study the effects of prior infection on vaccine efficacy. We injected three antigens sequentially. The first antigen, designated the prior, represented a prior infection or vaccination. The second antigen, the vaccine, represented a single component of the trivalent influenza vaccine. The third antigen, the epidemic, represented challenge by an epidemic strain. For a fixed vaccine to epidemic strain cross-reactivity, we generated prior strains over a fulldoi:10.1109/icsmc.1997.625777 fatcat:chvznhvs5rasdlqfkwrmxuit6m