In dairy animals, there are so many different conditions, which affect reproductive performance, and persistent corpus luteum (PCL) is one of those. It was suggested that this condition was difficult to treat and consequently result in lengthening of service period and calving interval. If this condition was not diagnosed and treated timely, it may result into permanent infertility and thereby huge loss to the breeders. The commercial availability of PGF2α and its analogues had promoted

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... nt and treatment of PCL in other part of the world on different breeds of cows with variable rates of success. This study was designed to determine the response of treatment of Sahiwal cows identified as having PCL with PGF2α (Dalmazin: Fatro Pharmaceutical). The present investigation has been conducted on Sahiwal cows maintained at Livestock Experimental Station, Bahadurnagar, Okara (Pakistan). The cows after 70 to 90 days post-partum were examined per rectum to check the condition of genitalia for PCL and this was also confirmed by progesterone assay in weekly blood samples for three weeks. All cows (n=20: mean weight, 402.0 ± 6.1 kg) sufferings from PCL were treated with 2 ml of Dalmazin intramuscularly on the same day. It was found that 85% of animals as determined by the examination of reproductive tracts and confirmed by progesterone analysis became normal and consequently 60% were pregnant at first service whereas 25% were repeat breeder. In conclusion, the treatment of Sahiwal cows, which were suffering from PCL, with PGF2α may correct this condition successfully.