Requirements and ontology for a G protein-coupled receptor oligomerization knowledge base

Lucy Skrabanek, Marta Murcia, Michel Bouvier, Lakshmi Devi, Susan R George, Martin J Lohse, Graeme Milligan, Richard Neubig, Krzysztof Palczewski, Marc Parmentier, Jean-Philippe Pin, Gerrit Vriend (+3 others)
2007 BMC Bioinformatics  
Commentary Requirements and ontology for a G protein-coupled receptor oligomerization knowledge base Lucy Skrabanek1'2, M arta M urcia1, Michel Bouvier3, Lakshmi Devi4, Susan R George5, M artin J Lohse6, Graeme M illigan7, Richard N eubig8, Krzysztof Palczewski9, Marc Parm entier10, Jean-Philippe P in 11, Gerrit V riend12, Jonathan A Javitch13, Fabien C am pagne1,2 and M arta Filizola* 1 A b s tra c t Backg rou nd : G Protein-Coupled Receptors (GPCRs) are a large and diverse family of membrane
more » ... roteins whose members participate in the regulation of most cellular and physiological processes and therefore represent key pharmacological targets. Although several bioinformatics resources support research on GPCRs, most of these have been designed based on the traditional assumption that monomeric GPCRs constitute the functional receptor unit. The increase in the frequency and number of reports about G PC R dimerization/oligomerization and the implication of oligomerization in receptor function makes necessary the ability to store and access information about G PC R dimers/oligomers electronically. Results: W e present here the requirements and ontology (the information scheme to describe oligomers and associated concepts and their relationships) for an information system that can manage the elements of information needed to describe comprehensively the phenomena of both homo-and hetero-oligomerization of GPCRs. The comprehensive information management BMC Bioinformatics 2007, 8:177 http://www.biomedcentral.eom/1471-2105 scheme that we plan to use for the development of an intuitive and user-friendly GPCR-Oligomerization Knowledge Base (G PC R-O KB) is the result of a community dialog involving experimental and computational colleagues working on GPCRs. C onclusion: O ur long term goal is to disseminate to the scientific community organized, curated, and detailed information about G P C R dimerization/oligomerization and its related structural context. This information will be reported as close to the data as possible so the user can make his own judgment on the conclusions drawn for a particular study. The requirements and ontology described here will facilitate the development of future information systems for G PC R oligomers that contain both computational and experimental information about G P C R oligomerization. This information is freely accessible at http://www.gpcr-okb.org.
doi:10.1186/1471-2105-8-177 pmid:17537266 pmcid:PMC1904246 fatcat:nqs47qalkrgkxfxobvmakai4um