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Dynamic Interstitial Cell Response During Myocardial Infarction Predicts Resilience to Rupture in Genetically Diverse Mice
2019
Social Science Research Network
Graphical Abstract Highlights d Longitudinal transcriptional profiling of cardiac interstitial cells post-infarct d Identification of epicardial versus endocardial origin of cardiac stromal cells d A distinct early injury-response signature precedes appearance of myofibroblasts d Modulation of early fibrosis predicts cardiac rupture and pathological remodeling SUMMARY Cardiac ischemia leads to the loss of myocardial tissue and the activation of a repair process that culminates in the formation
doi:10.2139/ssrn.3436216
fatcat:hy6slmlbsfeudabypxonh3dgni