Role of Matrix Metalloproteinases in Vascular Remodeling

Masafumi Kuzuya, Akihisa Iguchi
2003 Journal of atherosclerosis and thrombosis  
Vascular remodeling, defined as lasting structural changes in the vessel wall in response to hemodynamic stimuli, plays a role in many (patho)physiological processes requiring cell migration and degradation of extracellular matrix(ECM). Matrix metalloproteinase(MMP) system can degrade most ECM components. Several lines of evidence support a role for MMP system components in the development and progression of atherosclerosis and restenosis after angioplasty. This review article focuses on the
more » ... e focuses on the role of MMPs in vascular remodeling relevant to atherosclerosis and restenosis after angioplasty. J Atheroscler Thromb, 2003; 10: 275-282.
doi:10.5551/jat.10.275 pmid:14718744 fatcat:j4i4dfe3enccxgybtxr5wqskum