1679 with his usual clearness and precision." Essentially regarding induration as indifferently affecting either the lymphatic vessel or gland rather than apparently attaching importance to locality of lesion he noted that the induration of the vessel is often in inverse proportion to that of the primary sore or gland and he thought if such induration appeared shortly after infection and remained its" existence would be a sign .of the patient being syphilitic " or, in less marked form, the

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... ct of re-infection. I am, Sirs, yours faithfully, 'Grosvenor-street, W