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Paternal cigarette smoke alters DNA methylation in sperm and gene expression in offspring brain
[article]
2019
bioRxiv
pre-print
There is growing evidence that paternal pre-conception cigarette smoke (CS) exposure is associated with increased risk of behavioral disorders and cancer in offspring. The aim of the current study was to evaluate the impact of paternal pre-conception CS exposure on sperm DNA methylation and offspring phenotype. Methodology/Principal: To characterize the effects of CS exposure on the sperm epigenome and offspring neurodevelopment, we exposed male mice to CS and bred exposed and control males to
doi:10.1101/750638
fatcat:tukuypqewfh7rc5ufci2gvn374