Internet Archive Scholar

Aneurysm and Helicobacter pylori relationship: the seropositivity of CagA, VacA and other antigens of Helicobacter pylori in abdominal and ascending aortic aneurysms

Tevhide Ziver, Pelin Yuksel, Gokhan Ipek, Ibrahim Yekeler, Zehra Bayramoglu, Emin Tireli, Suat Saribas, Mustafa Aslan, Seyma Denli Yalvac, Ibrahim Ozdomanic, Zuhal Torlak, Ahmet Dirican (+2 others)
2010 The New Microbiologica  

Preserved Fulltext

fulltext thumbnail
Web Archive Capture PDF (163.3 kB)
https://web.archive.org/web/20170809104758/http://www.newmicrobiologica.org/PUB/allegati/2010_3/Micro3_07_Ziver.pdf

A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2017; you can also visit the original URL. The file type is application/pdf.

Helicobacter pylori is thought to be related to atherosclerosis and aneurysm development. We aimed to detect virulance factors of H. pylori and examine the potential etiopathogenetic relationship between aortic aneurysm and H. pylori, 58 abdominal aortic aneurysm (AAA) and 38 ascending aortic aneurysm (AsAA) cases and 57 Healty control group (HCG) were included. We investigated H. pylori IgG by ELISA and virulance factors by Western-Blot (WB) method. No difference was found between AAA
more » ... AsAA (73.68%) and HCG (57.89%) for H. pylori IgG (p > 0.05). A significant difference was found between AsAA (78.95%) and HCG (57.89%) for H.pylori IgG (p < 0.05) by ELISA and a significant difference was found only between AsAA (100%) and HCG (37.5%) for H. pylori IgG in the 45-55 age group by WB. A statistically significant difference was found between AAA and AsAA for VacA and CagA + VacA and CagA + VacA + UreA antigens and also a significant difference was found between AsAA and HCG for CagA + UreA antigens (p < 0.05). Finally, we suggest that H. pylori VacA has a more important role than CagA in the development of two aneurysms especially in ruptured AAA. New extended studies detecting H. pylori DNA are needed to detect the aetiopathogenesis between aneurysm types and H. pylori.
pmid:20954441 fatcat:2udu5jp7izarbflkt6hyfmw3mq
Citation

Tevhide Ziver, Pelin Yuksel, Gokhan Ipek, Ibrahim Yekeler, Zehra Bayramoglu, Emin Tireli, Suat Saribas, Mustafa Aslan, Seyma Denli Yalvac, Ibrahim Ozdomanic, Zuhal Torlak, Ahmet Dirican, Muzeyyen Mamal Torun, Bekir Kocazeybek. "Aneurysm and Helicobacter pylori relationship: the seropositivity of CagA, VacA and other antigens of Helicobacter pylori in abdominal and ascending aortic aneurysms." The New Microbiologica 33.3 (2010) 233-42