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Plasticity in Colorectal Cancer: Why Cancer Cells Differentiate
The cancer stem cell hypothesis poses that the bulk of differentiated cells are non-tumorigenic and only a subset of cells with self-renewal capabilities drive tumor initiation and progression. This means that differentiation could have a tumor-suppressive effect. Accumulating evidence shows, however, that in some solid tumors, like colorectal cancer, such a hierarchical organization is necessary. The identification of Lgr5 as a reliable marker of normal intestinal epithelial stem cells,doi:10.3390/cancers13040918 pmid:33671641 fatcat:jupzsvlhq5gunkvbu4wutzmzua