We conjecture two combinatorial interpretations for the symmetric function Δ_e_k e_n, where Δ_f is an eigenoperator for the modified Macdonald polynomials defined by Bergeron, Garsia, Haiman, and Tesler. Both interpretations can be seen as generalizations of the Shuffle Conjecture of Haglund, Haiman, Remmel, Loehr, and Ulyanov, which was proved recently by Carlsson and Mellit. We show how previous work of the third author on Tesler matrices and ordered set partitions can be used to verify

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... l cases of our conjectures. Furthermore, we use a reciprocity identity and LLT polynomials to prove another case. Finally, we show how our conjectures inspire 4-variable generalizations of the Catalan numbers, extending work of Garsia, Haiman, and the first author.