Moving Forward: Mechanisms of Chemoattractant Gradient Sensing

Jonathan Franca-Koh, Peter N. Devreotes
2004 Physiology  
Cells use an internal compass to sense the direction of chemoattractant gradients. This is used to bias pseudopod extension at the front of the cell and to orient cell polarization. Recent studies have highlighted the important roles played by phosphoinositide-3,4,5-triphosphate and small G proteins, but many questions remain.
doi:10.1152/physiol.00017.2004 pmid:15381759 fatcat:w3jw4sxhcjdkdmipseysp6kcoi