Infections [chapter]

Simon D. Message, Sebastian L. Johnston
2002 Asthma and COPD  
Asthma affects 20-33% of children in the UK. 1 It is a multifaceted syndrome involving atopy, bronchial hyperreactivity and IgE and non-IgE mediated acute and chronic immune responses. The asthmatic airway is characterized by an infiltrate of eosinophils and of T lymphocytes expressing the type 2 cytokines IL-4, IL-5 and IL-13. Trigger factors associated with acute exacerbations of asthma include exposure to environmental allergens, especially animals, molds, pollens and mites, cold, exercise
more » ... s, cold, exercise and drugs.The link between respiratory infection and asthma exacerbations is well established, although incompletely understood. In the 1950s this association was attributed to bacterial allergy, 2 but it is now clear that the majority of exacerbations are due to viral rather than bacterial infection. Infections
doi:10.1016/b978-012079028-9/50114-9 fatcat:s73qiwqv2rdqfjk4i7htdtdmx4