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The in vitro metabolism of mevalonate by sterol and non-sterol pathways
Journal of Biological Chemistry
The metabolism of mevalonic acid by both sterol and non-sterol pathways has been evaluated in nine tissues of the rat. An in vitro estimation of the non-sterol, or "shunt", pathway of mevalonate metabolism was made possible by determining the conversion of [2-14C]mevalonate or [5-14C]mevalonate to 14CO2 in tissue slices. In confirmation of our previous results, the kidney was found to play a major role in the metabolism of mevalonate to sterols and sterol precursors. The shunt pathway accountedpmid:1262340 fatcat:tuqsex4sifdubljc6yqwdcwxaa