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Peruvoside, a Cardiac Glycoside, Induces Primitive Myeloid Leukemia Cell Death
2016
Molecules
Despite the available chemotherapy and treatment, leukemia remains a difficult disease to cure due to frequent relapses after treatment. Among the heterogeneous leukemic cells, a rare population referred as the leukemic stem cell (LSC), is thought to be responsible for relapses and drug resistance. Cardiac glycosides (CGs) have been used in treating heart failure despite its toxicity. Recently, increasing evidence has demonstrated its new usage as a potential anti-cancer drug. Ouabain, one of
doi:10.3390/molecules21040534
pmid:27110755
fatcat:ei62n56swvawhblb42uopb5dqq