Baclofen Inhibited the Morphine-induced Conditioned Placed Preference and Withdrawal Syndromes

Hai-chen NIU, Bin SHANG, Ling LI, Ning-lei SUN, Yi-liang GUAN, Hua-lin YU, Yuan-ye MA
2009 Zoological Research  
摘要:小鼠连续 7 天腹腔注射吗啡(40 mg/kg)建立条件化位置偏好模型,连续皮下递增注射吗啡(25、50、 75、100、125、150 mg/kg) ,成瘾后腹腔注射纳络酮(6 mg/kg)诱导戒断症状(跳跃行为)建立戒断模型。腹腔 The mice with a continuous 7-day intraperitoneal injection of morphine was induced the conditioned placed reference (CPP) model and the mice with a continuous 7-day subcutaneous injection of morphine(25, 50, 75, 100, 125, 150 mg/kg)was induced withdrawal model (jump behavior) by naloxone administration(6 mg/kg). The results suggested that the administration of the GABA B
more » ... of the GABA B receptor agonist, baclofen, could effectively attenuate the expression of CPP and the nalxone-induced response in the mice. It could be concluded that activating GABA B receptor can alleviate physical and psychic dependence syndromes to a certian extent .
doi:10.3724/sp.j.1141.2008.06621 fatcat:foxgnhbcovhb5ky5wvgggapy3y