Synthesis of New α-Glucosidase Inhibitors Based on Oleanolic Acid Incorporating Cinnamic Amides

Wei Nie, Jian-Guang Luo, Xiao-Bing Wang, Hong Yin, Hong-Bin Sun, He-Quan Yao, Ling-Yi Kong
2011 Chemical and pharmaceutical bulletin  
A series of a a-glucosidase inhibitors with the oleanolic acid core and different cinnamic amide ligands were designed and synthesized. Their preliminary structure-activity relationships were analyzed. In general, the compounds with 3,28-disubstituted oleanolic acid exhibited stronger activity than those 28-monosubstituted analogues, and variation of cinnamic amide substitution significantly affected a a-glucosidase inhibition activities. Most of the compounds showed potent inhibitory activity
more » ... nhibitory activity against a a-glucosidase with much greater efficacy than a typical a a-glucosidase inhibitor, acarbose.
doi:10.1248/cpb.59.1051 pmid:21804254 fatcat:zt34xonanze2vajfyc3s3oeame