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A series of a a-glucosidase inhibitors with the oleanolic acid core and different cinnamic amide ligands were designed and synthesized. Their preliminary structure-activity relationships were analyzed. In general, the compounds with 3,28-disubstituted oleanolic acid exhibited stronger activity than those 28-monosubstituted analogues, and variation of cinnamic amide substitution significantly affected a a-glucosidase inhibition activities. Most of the compounds showed potent inhibitory activitydoi:10.1248/cpb.59.1051 pmid:21804254 fatcat:zt34xonanze2vajfyc3s3oeame