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The CBP KIX domain regulates long-term memory and circadian activity
2020
BMC Biology
CREB-dependent transcription necessary for long-term memory is driven by interactions with CREB-binding protein (CBP), a multi-domain protein that binds numerous transcription factors potentially affecting expression of thousands of genes. Identifying specific domain functions for multi-domain proteins is essential to understand processes such as cognitive function and circadian clocks. We investigated the function of the CBP KIX domain in hippocampal memory and gene expression using CBPKIX/KIX
doi:10.1186/s12915-020-00886-1
pmid:33121486
pmcid:PMC7597000
fatcat:l3avakvri5grpbrjxbmeuipbgu