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The diversity of molecular states and cellular plasticity of immune cells within the glioblastoma (GBM) environment remain poorly investigated. Here, we performed deep transcriptional profiling of lymphoid and myeloid cell populations by scRNA-sequencing, and mapped potential cellular interactions and cytokine responses that lead to the dysfunctional and exhausted phenotype of T cells. We identified the Interleukin 10 (IL-10) response during T cell activation as leading to a dysfunctional statedoi:10.1101/2020.06.01.121467 fatcat:q45xqdnoa5gglougojdttp6dei